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The benchmark outcome measure in 1,000+ antidepressant clinical trials and the standard for establishing treatment response and remission.",[14,15,17],"h2",{"id":16},"what-is-the-ham-d","What is the HAM-D?",[10,19,20],{},"The HAM-D (Hamilton Depression Rating Scale), also called the HDRS or HRSD, is a\n17-item clinician-administered rating scale developed by Max Hamilton in 1960 to quantify the severity\nof depressive illness. It is the most widely used observer-rated scale for measuring depression in\npharmacological research and has been used as the primary outcome measure in the majority of\nantidepressant clinical trials.",[10,22,23],{},"Items are rated on either a 5-point scale (0–4) or a 3-point scale (0–2), depending on the symptom.\nThe 17-item version (HAM-D17) is standard, yielding total scores from 0 to 52. Items assess mood,\nguilt, suicidality, insomnia, work and activity, psychomotor retardation, agitation, anxiety,\nsomatic symptoms, and vegetative features including appetite, libido, and weight.",[10,25,26],{},"The HAM-D is administered by a trained clinician through a semi-structured interview. It captures\nsymptoms over the past week and is particularly sensitive to melancholic features. A ≥50% reduction\nfrom baseline defines treatment response; a score of ≤7 defines remission, the two endpoints that\nanchor FDA antidepressant approval trials.",[14,28,30],{"id":29},"ham-d-score-interpreter","HAM-D Score Interpreter",[10,32,33],{},"Enter a total HAM-D17 score to see severity classification and clinical context.",[10,35,36],{},"For educational reference only. 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